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¹ Department of Aquaculture, Faculty of Fisheries and Marine Science, IPB University, Bogor, West Java 16680, Indonesia
² Aquacell Indo Pasifik, Gunung Sindur, Bogor, West Java 10270, Indonesia
³ Department of Aquaculture, Faculty of Animal Husbandry, Marine Science, and Fisheries, University of Nusa Cendana, Kupang, East Nusa Tenggara 85228, Indonesia DOI : 10.4194/AQUAST2905 Viewed : 499 - Downloaded : 344 Outbreaks of Aeromonas hydrophila cause major losses in African catfish (Clarias gariepinus) farming, while antibiotic raises resistance concerns. This study evaluated bacteriophages from a diseased catfish pond as local biocontrol agents. In vitro, phages reduced bacterial density by over 50% within 24 h (P<0.05). In vivo, phage treatment significantly improved survival compared with infected controls (P<0.05) and moderated hematological disruption. After infection, clinical signs were milder in phage-treated fish than in non-treated control. These results indicate that locally sourced phages can mitigate A. hydrophila infection and support future disease management in C. gariepinus aquaculture. Keywords : Bacterial Biocontrol Clarias gariepinus Motile Aeromonas septicemia Phage Therapy Sustainable Aquaculture