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¹ Islamic Azad University, Faculty of Basic Sciences, Department of Microbiology, Science and Research Branch, Tehran, Iran
² Islamic Azad University, Faculty of Basic Sciences, Department of Biology, Roudehen Branch, Tehran, Iran. DOI : 10.4194/AQUAST991 Viewed : 977 - Downloaded : 1047 This study aimed to evaluate the effect of Lactobacillus fermentum ATCC 14931 as a probiotic to improve immune function and reduce the adverse effects of cadmium (Cd) in zebrafish. This study was performed for 60 days of feeding and 72 hours exposure to 7 g/L Cd. The study groups included C: Control, B: Feeding with a basal diet and exposure to cd, T1 and T3: feeding with probiotic diet in concentrations of 1.5×10⁴ and 1.5×10⁵ CFU ml^-1 and exposure to cd, respectively. The biometrical index, mortality rate, Cd accumulation in tissue, superoxide dismutase (SOD) activity, and concentration of malondialdehyde (MDA) were examined. According to the results, feeding with probiotics increased the length and weight growth of fish (P<0.05). The mortality rate in probiotic-fed groups was significantly reduced (P<0.05), while no significant difference was recorded in the cd accumulation rate of the gastrointestinal tract (P>0.05). Also, the SOD activity and MDA level decreased in T1 and T2 (P<0.05). Generally, the results showed that L. fermentum can be used as a suitable dietary supplement to prevent the adverse effects of acute Cd exposure in fish. Keywords : Lactobacillus fermentum Zebrafish Cadmium MDA SOD